Koh, Sang-Seok

Professor Sang-Seok Koh, PhD

Biographical Information

Sang Seok Koh attended the Seoul National University obtaining a B.S. in Microbiology, an M.S. in Microbial Genetics, and Ph.D. in Molecular Genetics. He was a Post-Doctoral Research Scientist in Whitehead Research center, MIT (1994 – 1999). He was employed as a Research Scientist in the LG Biomedical Institute in Korea and the USA (1999 – 2006). He was a Principal Investigator in Antibody Therapy and Immunotherapy Research Centers in Korea Research Inst. of Bioscience and Biotechnology in Korea (2006 – 2014). And he is employed as a Professor in the Department of Biological Sciences of Dong-A University in Busan, Korea since 2014. He has published over 70 papers and applied and registered more than 20 patents. Now he is studying the interaction between tumor cells and surrounding stromal or immune cells in the tumor microenvironment and is developing therapeutic antibodies that can neutralize pancreatic cancer-specific upregulated factors.

Ten selected published papers

1. Song H, Song J, Kim YJ, Jeong HH, Min HJ, Koh SS DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer. Biochemical and Biophysical Research Communications 2017 Dec;493(4):1498-1503
2. Lee J, Song J, Kwon E-S, Jo S, Kang MK, Kim YJ, Hwang Y, Bae H, Kang TH, Chang S, Cho HJ, Kim SC, Kim S, Koh SS CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors. Experimental and Molecular Medicine 2016 Sep;48(9):e261
3. Song J, Lee J, Kim J, Jo S, Kim YJ, Baek JE, Kwon E-S, Lee K-P, Yang S, Kwon K-S, Kim D-U, Kang TH, Park Y-Y, Chang S, Cho HJ, Kim SC, Koh SS, Kim S Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid derived suppressor cells (MDSCs) in pancreatic cancer. Oncotarget 2016 Aug;7(32):51840-51853
4. Kaowinn S, Cho-I-R, Moon J, Jun SW, Kim CS, Kang HY, Kim M, Koh SS, Chung Y-H Pancreatic adenocarcinoma upregulated factor (PAUF) confers resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNA receptor-mediated signaling.Biochemical and Biophysical Research Communications 2015 Apr;459(2):313-318
5. Kim SJ, Chang S, Lee Y, Kim NY, Hwang Y, Min HJ, Yoo K-S, Park EH, Kim S, Chung Y-H, Park YW, Koh SS A PAUF-neutralizing antibody targets both carcinoma and endothelial cells to impede pancreatic tumor progression and metastasis. Biochemical and Biophysical Research Communications 2014 Nov;454(1):144-150
6. Kim YH, Moon JY, Kim EO, Lee SJ, Kang SH, Kim SK, Heo K, Lee Y, Kim H, Kim K, Kim D, Song MS, Lee SW, Lee Y, Koh SS, Kim IH Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model. Cancer Letters 2014 Mar;344(2):223-231
7. Kim SJ, Lee Y, Kim NY, Hwang Y, Hwang B, Min J-K, Koh SS Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability. Oncogene 2013 Aug;32(31):3638-3647
8. Park EH, Kim S, Jo JY, Kim SJ, Hwang Y, Kim J-M, Song SY, Lee D-K, Koh SS Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. Carcinogenesis 2013 Mar;34(3):694-702
9. Lee Y, Kim SJ, Min HJ, Jo JY, Park EH, Koh SS PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase. Experimental and Molecular Medicine 2011 May;43(5):291-297
10. Lee Y, Kim SJ, Park HD, Park EH, Huang SM, Jeon SB, Kim JM, Lim DS, Koh SS PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression. Oncogene 2010 Jan;29(1): 56-67

<style> p{ font-family: } .p1 { font-size:14px; line-height:150%; } .p2 { font-size:17px; line-height:150%; } </style> <h2 class="bullet">Professor Sang-Seok Koh, PhD</h2> <br><br> <img width="193" height="270" src="/sites/bk4health/images/210709_06.png"></p><br><br> <p class="p1">Biographical Information<br> <br> Sang Seok Koh attended the Seoul National University obtaining a B.S. in Microbiology, an M.S. in Microbial Genetics, and Ph.D. in Molecular Genetics. He was a Post-Doctoral Research Scientist in Whitehead Research center, MIT (1994 – 1999). He was employed as a Research Scientist in the LG Biomedical Institute in Korea and the USA (1999 – 2006). He was a Principal Investigator in Antibody Therapy and Immunotherapy Research Centers in Korea Research Inst. of Bioscience and Biotechnology in Korea (2006 – 2014). And he is employed as a Professor in the Department of Biological Sciences of Dong-A University in Busan, Korea since 2014. He has published over 70 papers and applied and registered more than 20 patents. Now he is studying the interaction between tumor cells and surrounding stromal or immune cells in the tumor microenvironment and is developing therapeutic antibodies that can neutralize pancreatic cancer-specific upregulated factors.</p> <br><br> <p class="p1">Ten selected published papers </p> <br><br> <ol> <li>Song H, Song J, Kim YJ, Jeong HH, Min HJ, <strong>Koh SS</strong> DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer. Biochemical and Biophysical Research Communications 2017 Dec;493(4):1498-1503 </li> <li>Lee J, Song J, Kwon E-S, Jo S, Kang MK, Kim YJ, Hwang Y, Bae H, Kang TH, Chang S, Cho HJ, Kim SC, Kim S, <strong>Koh SS</strong> CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors. Experimental and Molecular Medicine 2016 Sep;48(9):e261</li> <li>Song J, Lee J, Kim J, Jo S, Kim YJ, Baek JE, Kwon E-S, Lee K-P, Yang S, Kwon K-S, Kim D-U, Kang TH, Park Y-Y, Chang S, Cho HJ, Kim SC, <strong>Koh SS</strong>, Kim S Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid derived suppressor cells (MDSCs) in pancreatic cancer. Oncotarget 2016 Aug;7(32):51840-51853</li> <li>Kaowinn S, Cho-I-R, Moon J, Jun SW, Kim CS, Kang HY, Kim M, <strong>Koh SS</strong>, Chung Y-H Pancreatic adenocarcinoma upregulated factor (PAUF) confers resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNA receptor-mediated signaling.Biochemical and Biophysical Research Communications 2015 Apr;459(2):313-318</li> <li>Kim SJ, Chang S, Lee Y, Kim NY, Hwang Y, Min HJ, Yoo K-S, Park EH, Kim S, Chung Y-H, Park YW, <strong>Koh SS</strong> A PAUF-neutralizing antibody targets both carcinoma and endothelial cells to impede pancreatic tumor progression and metastasis. Biochemical and Biophysical Research Communications 2014 Nov;454(1):144-150</li> <li>Kim YH, Moon JY, Kim EO, Lee SJ, Kang SH, Kim SK, Heo K, Lee Y, Kim H, Kim K, Kim D, Song MS, Lee SW, Lee Y, <strong>Koh SS</strong>, Kim IH Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model. Cancer Letters 2014 Mar;344(2):223-231</li> <li>Kim SJ, Lee Y, Kim NY, Hwang Y, Hwang B, Min J-K, <strong>Koh SS</strong> Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability. Oncogene 2013 Aug;32(31):3638-3647</li> <li>Park EH, Kim S, Jo JY, Kim SJ, Hwang Y, Kim J-M, Song SY, Lee D-K, <strong>Koh SS </strong>Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. Carcinogenesis 2013 Mar;34(3):694-702</li> <li>Lee Y, Kim SJ, Min HJ, Jo JY, Park EH, <strong>Koh SS</strong> PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase. Experimental and Molecular Medicine 2011 May;43(5):291-297</li> <li>Lee Y, Kim SJ, Park HD, Park EH, Huang SM, Jeon SB, Kim JM, Lim DS, <strong>Koh SS</strong> PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression. Oncogene 2010 Jan;29(1): 56-67</li> </ol>